The total number of chromosomes in our body is 46. Out of 46, 23 chromosomes come from our mothers and the other 23 come from our fathers. In Down syndrome, chromosome number 21 has 3 copies, rather than 2. This is why DS is also known as Trisomy 21. As a result, the total number of chromosomes in DS becomes 47, not 46.
Source: www.downturkiye.com